Substrates for Acoustofluidics Research & Production

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Silicon on Glass wafers for Acoustofluidics Research

Silicon on glass wafers to combine microfluidics with acoustics to manipulate particles in a fluid cavity. 100mm glass wafer with 30-50 µm Silicon thickness on top of a Glass Wafer with 20-1000 µm thickness.

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What is Acoustofluidics Research?

In the last two decades, we have witnessed the emergence of a completely new field of research in microfluidics: acoustofluidic research. A new laboratory - on - one chip has been created that combines acoustic with acoustic or acoustic fluids. [Sources: 3]

The acoustic fluidic device uses surface acoustic waves (SAWs) as a source of drive and contains an elastic nanolayer located at the interface between the microfluidic channel and the acoustic converter. By using the unique nanoscale acoustic force field to overcome the Brownian motion of the acoustic stream, the team was able to manipulate the nanOCavities in a way similar to that of a real acoustic wave source. The simulated flow shows that targets (i.e. fluorescent particles) focused within the expected focus range can be collected in the middle channel and concentrated ten times. [Sources: 2, 6]

In addition, the high purity and yield properties enable the efficiency of genomic and proteomic profiling in liquid biopsies to be significantly improved. The thin glass microfluidic device, which can contribute to the development of high-quality, cost-effective and environmentally friendly organic products, is capable of separating mixed particles of different sizes. [Sources: 5, 6]

One of the main tasks of his scholarship is the implementation of a new holistic principle - the system resonance principle. The proposed research programme involves the development of a phonic crystal that takes into account all the fundamental properties of phonics, such as the resonance of sound and the interaction between the sound wave and its components. [Sources: 0, 1]

Due to its advantages, acoustic focusing is considered a promising method for the investigation of particles in narrow spaces in microfluidic devices. The use of a focused acoustic field results in highly localized acoustic streaming and high particle concentration. [Sources: 6]

Glass thickness in microfluidic devices is an important parameter for acoustic focusing, as it strongly correlates with the energy propagation of acoustic waves (see SS2). As expected, acoustic pressure nodes can be located in a device thinner than 0.2 mm, which has been used in many acoustic-focused experiments in the past (e.g. as discussed later in electronic auxiliary material). For future studies that wish to investigate the acoustic properties of a glass - composite microfluidic device or other material than glass - its acoustic focusing capability is not as strong as that of glass composite microfluidization devices. Recently, the use of tilt angle or input (TID) devices, used to measure particle concentration and particle separation, has been used for size-based separation, but only for small acoustic focus tests and not for larger-than-normal acoustic studies. [Sources: 6, 8]

The force of the acoustic radiation in this study is almost comparable to equation (2.2), taking into account the difference in thickness of the microfluidic device and its acoustic focusing ability, while the differences in thickness in microfluidic devices are neglected. Since the energy input outside our study (piezoelectric transducer) is constant and the effect of glass thickness on the acoustic energy propagation of acoustic waves is negligible, we consider this to be a constant. This can be found in the equations (1,4) and (3,1) for glass and glass composites respectively. [Sources: 6, 7]

The research project involved doctoral and postdoctoral students from SUTD, including students from the Faculty of Electrical Engineering and Computer Science and Engineering (DSE), Richard Chen, Yoon-Hui Li and Cheng Chen. The researchers say the research relied heavily on the help of students, most of whom interrupted other projects to focus on this. [Sources: 2, 4]

The researchers recently joined an international group of experts led by the Department of Electrical Engineering and Computer Science at DTU. This group usually consists of up to eight members, including researchers from the Faculty of Engineering, the Faculty of Physics and Astronomy and the College of Arts and Sciences (CAS). Further information on the research project and other research activities of SUTD can be found at www. The University of Hong Kong and its affiliated universities offer a wide range of bachelor, postdoctoral and doctoral degrees in electrical engineering, computer science and engineering, while DTD is one of the world's leading technical universities, recognised as one of the 10 leading technical universities in the world in electrical engineering and mechanical engineering. [Sources: 0, 4]

The fusion of phonics and microfluidics could open the door to a whole new world of applications in quantum information processing. How have electrons and photons evolved so far and how can we use new technologies to enable rapid development in this area? [Sources: 1, 3]

The aim of this research proposal is to investigate the possibility of developing microfluidic devices with new functionalities that use phonic crystals on a silicon substrate. [Sources: 1]

We first investigate ultra-thin glass microfluidic devices by diluting them with a thin layer of silicon and then using them to determine the degree of acoustic focusing by inserting micro-anoparticles of various diameters from 500 nm to 10 nm. We then examine how thin the glazing of the microfluidic device is suitable for acoustic - the focusing of flowing beads, as theoretical calculations expect - in order to determine the feasibility of such a device as an ideal candidate for the development of new functionalities. Finally, we study the acoustic properties of microfluidic glasses to see if it is possible to find certain degrees of acoustic focusing in devices of extreme thickness. [Sources: 6]

 

 

Sources:

[0]: https://www.academicgates.com/job/detail/00155d140103-11e9-bae2-3b6f639e-9ce4

[1]: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1642502

[2]: https://phys.org/news/2020-05-scientists-acoustofluidic-technology-isolates-submicron.html

[3]: https://www.mae.ncsu.edu/event/seminar-acoustofluidics-merging-acoustics-and-microfluidics-for-biomedical-applications-dr-huang/

[4]: https://twin-cities.umn.edu/news-events/new-study-explores-how-coronavirus-travels-indoors

[5]: https://www.jmdjournal.org/article/S1525-1578(19)30395-2/fulltext

[6]: https://royalsocietypublishing.org/doi/10.1098/rsos.181776

[7]: https://www.nature.com/articles/s41378-019-0064-3

[8]: https://www.mdpi.com/2072-666X/7/12/216/htm